HIBAG—HLA genotype imputation with attribute bagging
نویسندگان
چکیده
منابع مشابه
Genotype imputation.
Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individu...
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Genotype imputation is a statistical technique that is often used to increase the power and resolution of genetic association studies. Imputation methods work by using haplotype patterns in a reference panel to predict unobserved genotypes in a study dataset, and a number of approaches have been proposed for choosing subsets of reference haplotypes that will maximize accuracy in a given study p...
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Filtered Attribute Subspace based Bagging with Injected Randomness (FASBIR) is a recently proposed algorithm for ensembles of k-nn classifiers [28]. FASBIR works by first performing a global filtering of attributes using information gain, then randomising the bagged ensemble with random subsets of the remaining attributes and random distance metrics. In this paper we propose two refinements of ...
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Most current genotype imputation methods are model-based and computationally intensive, taking days to impute one chromosome pair on 1000 people. We describe an efficient genotype imputation method based on matrix completion. Our matrix completion method is implemented in MATLAB and tested on real data from HapMap 3, simulated pedigree data, and simulated low-coverage sequencing data derived fr...
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Several methods have been proposed to impute genotypes at untyped markers using observed genotypes and genetic data from a reference panel. We used the Genetic Analysis Workshop 16 rheumatoid arthritis case-control dataset to compare the performance of four of these imputation methods: IMPUTE, MACH, PLINK, and fastPHASE. We compared the methods' imputation error rates and performance of associa...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2013
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2013.18